New Delhi: Hypertension affects approximately 32% of the world’s adult population. In India, 1 in 3 people is a patient with high blood pressure. This is why the demand for antihypertensive drugs is constantly on the rise. Different types of side effects are seen with existing blood pressure lowering medicines. As a result, the pressure to find new antihypertensive drugs is constantly increasing.
This medicine lowers blood pressure
Scientists from Banasthali Vidyapith’s pharmacy division have discovered a new antihypertensive drug that will lower blood pressure in the future. This will also help treat angina and other heart-related conditions. This research work was published in August 2020 in the prestigious American Chemical Society Journal.
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Medicine made with the help of computer software
The head of the Pharmacy Department of Banasthali University Prof. Research conducted by Sarvesh Paliwal and his team members, Dr. Swapnil Sharma and Dr. Seema Kesar, has shown that this drug inhibits the enzyme Enzyme (RHO kinase). A major cause of elevated blood pressure in humans is the ROCK enzyme (RHO kinase). This drug shows its effect on rock enzyme 2. It is noteworthy and important here that only one drug of this class is Fasudil, which is available in Japan (Japan) and China (China). He also holds the patent rights to this drug. Therefore, this research has special significance in the context of India and other parts of the world. Pro. According to Paliwal, Computer Aided Drug Design-CADD technique played a very important role in the discovery of this drug. CADD is a computer technique that makes it possible to discover new drugs using various computer software.
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5 years of research
Pro. Paliwal said this research work started 5 years ago and after testing about 3 lakh samples, it got success. After testing on mice, it was discovered that this drug can be seen as an alternative to high blood pressure drugs in the future. Pro. According to Paliwal, in the full funding of this project, Vice Chancellor, Vice Chancellor of Banasthali Vidyapith, Prof. Aditya Shastri has made an unprecedented contribution. He constantly encouraged team members in this research work.
Following the success of this research work, the scientists at Banasthali Vidyapith have started the process of the next phase, namely the clinical trial.
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